Goat Secondary Antibodies
Cayman Chemical 2′-O-Methylcytidine, Purity: ≥98%, CAS: 2140-72-9, 1 g
An inhibitor of HCV NS5B (IC50 = 3.8 µM); inhibits HCV replication in a replicon assay (IC50 = 21.2 µM)
Cayman Chemical Stachyose (hydrate), Purity: ≥95%, CAS: 54261-98-2, 5 g
An oligosaccharide and prebiotic; reduces the number of colonic lesions and serum TNF-α, IL-6, IL-10, and IL-17a levels, as well as increases gut levels of Akkermansia and Lactobacillus, in a rat model of DSS-induced colitis at 1 g/kg per day; decreases serum LPS, IL-6, and TNF-α levels and enriches Phascolarctobacterium, Bilophila, Oscillospira, and Turicibacter in the gut microbiota in a rat model of STZ- and high-fat diet-induced diabetes; enhances berberine-induced blood glucose control and improvements in insulin resistance, as well as decreases the fecal concentration of short-chain fatty acids, in the KKAγ mouse model of type 2 diabetes
Cayman Chemical Pinacidil (hydrate), Purity: ≥95%, CAS: 85371-64-8, 250 mg
A potassium channel opener, activating the ATP-modulated potassium channels of guinea pig bladder and heart with Ki values of 104 and 251 nM, respectively; completely relaxes coronary artery rings preconstricted with serotonin (IC50 = 1.26 µM)
Cayman Chemical SIKVAV (acetate), Purity: ≥98%, 500 mg
A laminin α1-derived peptide; binds to α3, α6, and β1 integrins; induces adhesion of CAC2 adenoid cystic carcinoma cells at 1 µg/ml; stimulates the proliferation, migration, and secretion of EGF, VEGF, TGF-β, and FGF in primary mouse fibroblasts at 100 µg/ml; topical administration of a chitosan hydrogel containing SIKVAV promotes wound healing and angiogenesis in mice
Cayman Chemical Escitalopram (oxalate), Purity: ≥98%, CAS: 219861-08-2, 250 mg
A selective serotonin reuptake inhibitor; selectively binds to SERT (Ki = 0.89 nM) over the norepinephrine and dopamine transporters (Kis = >10,000 and 8,150 nM, respectively); inhibits 5-HT reuptake in rat brain synaptosomes (IC50 = 2.1 nM); reduces immobility in the forced swim test in mice (ED50 = 12 mg/kg) and increases exploratory behavior in the black-and-white box test in mice (MED = 0.49 mg/kg); prevents acid sphingomyelinase activation and subsequent ceramide release induced by pp-VSV-SARS-CoV-2 infection in Vero cells at 20 µM
Cayman Chemical 11-dehydro Thromboxane B2 Monoclonal Antibody, 100 dtn
11-dehydro Thromboxane B2 Monoclonal Antibody, 100 dtn
Cayman Chemical 4-Nitrodiphenylamine, Purity: ≥98%, CAS: 836-30-6, 1 g
An aromatic amine antioxidant; a component of both burnt gunshot residue and unburnt gunpowder
Cayman Chemical Octenidine (hydrochloride), Purity: ≥98%, CAS: 70775-75-6, 25 g
An antimicrobial agent; active against methicillin-sensitive and -resistant S. aureus, vancomycin-resistant Enterococcus, E. faecalis, S. pneumoniae, and C. albicans (MICs = 1-32 mg/L); reduces methicillin- or vancomycin-resistant S. aureus biofilm formation at 2 mM; reduces dental plaque accumulation in cynomolgus monkeys fed a high-sucrose diet at 1%
Cayman Chemical Pipemidic Acid (hydrate), Purity: ≥98%, CAS: 72571-82-5, 25 g
An antibiotic; active against clinical isolates of E. coli, P. mirabilis, P. inconstans, Shigella, Salmonella, Alcaligenes, and V. parahaemolyticus (MICs = 0.78-100 µg/ml), as well as drug-resistant clinical isolates of E. coli, P. mirabilis, Klebsiella, and Shigella (MICs = 1.56-6.25 µg/ml); Protective against systemic S. aureus, E. coli, K. pneumoniae, and P. aeruginosa infections in mice (ED50s = 237.5, 204.1, 28.6, and 99.5 mg/kg, respectively); protective against P. aeruginosa-induced pulmonary and dermal infections (ED50s = 81.7 and 173.2 mg/kg, respectively), as well as E. coli, K. pneumoniae, and P. aeruginosa urinary bladder infections (ED50s = 4.8, 11.9, and 30.6 mg/kg, respectively), in mice
Cayman Chemical Nuciferine, Purity: ≥98%, CAS: 475-83-2, 5 mg
An alkaloid with diverse biological activities; partial agonist at dopamine D2 receptors, as well as an inverse agonist at the serotonin receptor subtype 5-HT7, and an antagonist at the 5-HT2B and 5-HT2C receptors (EC50s = 65.07, 150, 478, and 131 nM, respectively); an antagonist at schistosome Sm.5-HTRL receptors (IC50 = 240 nM); inhibits 5-HT-induced motility of larval and adult S. mansoni at 10 µM; activates PPARα, PPARβ/δ, and PPARγ transcriptional activity; prevents RSL3-induced ferroptotic cell death in HK-2 and HEK293T cells at 10, 20, and 40 µM; reduces serum hyperlipidemia and hepatic steatosis in a mouse model of high-fat diet-induced hyperlipidemia
Cayman Chemical DL-erythro/threo-Isocitric Acid (sodium salt hydrate), Purity: ≥95%, 5 g
A mixture of isocitric acid isomers
Cayman Chemical 6-Methylmercaptopurine, Purity: ≥95%, CAS: 50-66-8, 250 mg
A metabolite of 6-MP; formed from 6-MP via methylation by thiopurine S-methyltransferase; levels are increased in patients with altered thiopurine metabolism and associated with therapeutic resistance to 6-MP
Cayman Chemical 5β-Dihydroprogesterone, Purity: ≥95%, CAS: 128-23-4, 500 mg
A progesterone receptor agonist and metabolite of progesterone; inhibits spontaneous contractions in isolated rat uterus at 10 µg/ml; a negative modulator of homooligomeric ρ1 subunit-containing GABAAreceptors expressed in X. laevis oocytes (IC50 = 5.02 µM); plasma levels decrease at the onset of spontaneous human labor
Cayman Chemical Cefquinome (sulfate), Purity: ≥98%, CAS: 118443-89-3, 250 mg
A broad-spectrum cephalosporin antibiotic; active against clinical isolates of various Gram-positive and Gram-negative bacteria, Salmonella, E. coli, and MRSA (MICs = 0.06-0.5, 0.015-0.5, and 1-16 µg/ml, respectively); intramammary administration is curative in a bovine model of E. coli-induced mastitis at 75 mg/animal